Endocrine Abstracts

Background: Pancreatic acinar cell carcinoma (PACC) is a rare cancer, comprising less than 1% of all pancreatic cancers and often presents as a mixed malignancy with a neuroendocrine component. Limited data exists on its clinical and molecular characteristics. This retrospective study aims to provide additional insights to better understand and characterize the disease.Methods: Patients from the Mayo Clinic with pathology records denoting pancreatic acin...

Background: Lu177 has shown efficacy in advanced NET with significant hematologic toxicity, including therapy-related myeloid neoplasm (t-MN). CH is defined by acquisition of somatic mutations in hematopoietic stem cells with potential for expansion over time. In this study, we aimed to assess the prevalence of CH in NET patients (pts) prior to Lu177 along with the incidence of cytopenia in NET pts treated with lu177 based on the CH status at baselineMet...